Publications
Schneider, M., Pons, J.-L., Labesse, G. & Bourguet, W. In Silico Predictions of Endocrine Disruptors Properties. Endocrinology 160, 2709–2716 (2019).Download
Schneider, M., Pons, J. L., Bourguet, W., Labesse, G. & Elofsson, A. Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity. Bioinformatics 36, 160–168 (2020).Download
den Broeder, M. J. et al. Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenetics Chromatin 13, 5 (2020).Download
Legler, J. et al. The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds. Int. J. Mol. Sci. 21, 3480 (2020).Download
X. M. Ren, Y. Kuo, B. Blumberg, Agrochemicals and obesity, Mol. Cell. Endocrinol. 515, 110926 (2020).Download
Massart, J., Begriche, K. & Fromenty, B. Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis. Clin Res Hepatol Gastroenterol 45, 101470 (2021).Download
Rodríguez-Mier, P., Poupin, N., de Blasio, C., Le Cam, L. & Jourdan, F. DEXOM: Diversity-based enumeration of optimal context-specific metabolic networks. PLoS Comput Biol 17, e1008730 (2021).Download
Garoche, C. et al. Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals. Environ Sci Technol 55, 16489–16501 (2021).Download
Martens, M. et al. ELIXIR and Toxicology: a community in development. F1000Research 2021 10:1129 10, 1129 (2021).Download
Lizano-Fallas, V., Carrasco del Amor, A. & Cristobal, S. Systematic analysis of chemical-protein interactions from zebrafish embryo by proteome-wide thermal shift assay, bridging the gap between molecular interactions and toxicity pathways. J Proteomics 249, 104382 (2021).Download
Delmas, M. et al. FORUM: building a Knowledge Graph from public databases and scientific literature to extract associations between chemicals and diseases. Bioinformatics 37, 3896–3904 (2021).Download
Delfosse, V. et al. Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures. Proc Natl Acad Sci U S A 118, e2020551118 (2021).Download
Audouze, K. et al. Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities. Frontiers in Toxicology 3, 787017 (2021).Download
Allard, J. et al. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells : proof of multiple mechanism-based toxicity, Cell. Biol. Toxicol. (2021).Download
Kassotis, C. D. et al. Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study. Toxicology 461, (2021).Download
Norgren, K. et al. High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs). Food and Chemical Toxicology 161, 112842 (2022).Download
Massart, J., Begriche, K., Hartman, J. H. & Fromenty, B. Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver. Cells 2022, Vol. 11, Page 288 11, 288 (2022).Download
Massart, J., Begriche, K., Corlu, A. & Fromenty, B. Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease. International Journal of Molecular Sciences 2022, Vol. 23, Page 1062 23, 1062 (2022).Download
Gruszczyk, J. et al. Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex. Nature Communications 2022 13:1 13, 1–13 (2022).Download
Santos, R. S. Dos, Medina-Gali, R. M., Babiloni-Chust, I., Marroqui, L. & Nadal, A. In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model. Int J Mol Sci 23, 5040 (2022).Download
Jacobs, M. N., Kubickova, B. & Boshoff, E. Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction. Frontiers in Toxicology 4, 880818 (2022).Download
Babiloni-Chust, I. et al. G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells. Environ Int 164, 107250 (2022).Download
Martyniuk, C. J. et al. Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities. Environ. Res. 204, 111904 (2022).Download
Cai, A. et al. Prenatal Exposure to Metabolism-Disrupting Chemicals, Cord Blood Transcriptome Perturbations, and Birth Weight in a Belgian Birth Cohort. Int J Mol Sci 24, 7607 (2023).Download
Martínez-Pinna, J. et al. Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus. Am J Physiol Endocrinol Metab 324, E488–E505 (2023).Download
Dos Santos, R. S., Babiloni-Chust, I., Marroqui, L. & Nadal, A. Screening of Metabolism-Disrupting Chemicals on Pancreatic α-Cells Using In Vitro Methods. Int J Mol Sci 24, 231 (2023).Download
Berlin, E., Lizano-Fallas, V., Carrasco del Amor, A., Fresnedo, O. & Cristobal, S. Nonionic Surfactants can Modify the Thermal Stability of Globular and Membrane Proteins Interfering with the Thermal Proteome Profiling Principles to Identify Protein Targets. Anal Chem 95, 4033–4042 (2023).Download
Sapounidou, M., Norinder, U. & Andersson, P. L. Predicting Endocrine Disruption Using Conformal Prediction – A Prioritization Strategy to Identify Hazardous Chemicals with Confidence. Chem Res Toxicol 36, 53–65 (2023).Download
Lizano-Fallas, V., Carrasco del Amor, A. & Cristobal, S. Prediction of Molecular Initiating Events for Adverse Outcome Pathways Using High-Throughput Identification of Chemical Targets. Toxics 11, 189 (2023).Download
Ren, X. M. et al. 2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors. Endocrinology 164, 1–11 (2023).Download
Kubickova, B. & Jacobs, M. N. Development of a reference and proficiency chemical list for human steatosis endpoints in vitro. Front Endocrinol (Lausanne) 14, 1126880 (2023).Download